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The Lab

Interventions

Sotatercept · activin inhibitor

Find Sotatercept · activin inhibitor in Pulmonary vasodilators. Sotatercept is an ActRIIA–Fc ligand trap that reduces excessive activin-related growth signaling. It is not a direct BMPR2 agonist or an acute rescue vasodilator.

Overview

Open Interventions → Pulmonary vasodilators. Choose Off, On. Effect levels and flow targets represent illustrative modeled responses; they are not clinical dose instructions.

Sotatercept is an ActRIIA–Fc ligand trap that reduces excessive activin-related growth signaling. It is not a direct BMPR2 agonist or an acute rescue vasodilator.

The paused reference covers the route (Subcutaneous maintenance injection; the simulation illustrates a later treatment endpoint.), example doses/settings, indications, adverse effects, contraindications/precautions and monitoring. These details are available after the intervention is selected.

What to monitor in the reference: Haemoglobin/platelets before each of the first 5 doses, longer if unstable, and periodically thereafter; bleeding, blood pressure, hypersensitivity and clinical/RV response.

Step by step

  1. Inspect the untreated disease and active treatment count.
  2. Apply the intervention and compare pressures, forward flow, rhythm and congestion.
  3. Pause for its full reference; use Off or Interventions Reset to restart the comparison.

References & further reading

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